CASE CENTER


Construction of Cryo Electron Microscopy Center at Shanxi Advanced Research Institute

Project timeline: 2019

Project Content: Engineering+Equipment

Project Address: Taiyuan City

The Cryo Electron Microscopy Center of Shanxi Higher Innovation Research Institute is affiliated with the Structural Science Platform of the Institute. It is the first and largest centralized cryo electron microscopy center in our province, equipped with 7 cryo electron microscopes of different specifications, and its main equipment configuration is internationally leading. As one of the most advanced and comprehensive platforms in the field of structural biology, it can provide the most advanced technological means for the study of the laws of life essence, the elucidation of the medical and health industry, and the research of emerging materials.

 

Since its operation, the Cryo Electron Microscopy Center of Shanxi Higher Innovation Research Institute has received high attention from provincial and municipal leaders, as well as various universities, research institutions, and medical institutions. Currently, it has served many universities and research institutions inside and outside the province, such as the Chinese Academy of Sciences and Shanxi University.

 

The Cryo Electron Microscopy Center of Shanxi Higher Innovation Research Institute, in collaboration with the Department of Biology of Southern University of Science and Technology and the Institute of Microbiology of the Chinese Academy of Sciences, has published a research paper on the capsid structure of varicella zoster virus in the internationally renowned journal Nature Communications. This study successfully resolved the fine three-dimensional structure of the VZV virus capsid using cryo electron microscopy technology, and analyzed the molecular mechanism of virus assembly and potential antiviral targets, providing important basis for the development of specific or broad-spectrum anti herpesvirus drugs.

 

In addition, the Cryo Electron Microscopy Center of Shanxi Higher Innovation Research Institute has collaborated with other research teams to publish a study on the self inhibition and activation mechanisms of STING proteins in Molecular Cell, further demonstrating the research strength and influence of the center in the field of structural biology.

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